Cannabidiol-from Plant to Human Body: A Promising Bioactive Molecule with Multi-Target Effects in Cancer
Cannabis sativa L. is a plant long used for its textile fibers, seed oil, and oleoresin with medicinal and psychoactive properties. It is the main source of phytocannabinoids, with over 100 compounds detected so far. In recent years, a lot of attention has been given to the main phytochemicals present in Cannabis sativa L., namely, cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC). Compared to THC, CBD has non-psychoactive effects, an advantage for clinical applications of anti-tumor benefits. The review is designed to provide an update regarding the multi-target effects of CBD in different types of cancer. The main focus is on the latest in vitro and in vivo studies that present data regarding the anti-proliferative, pro-apoptotic, cytotoxic, anti-invasive, anti-antiangiogenic, anti-inflammatory, and immunomodulatory properties of CBD together with their mechanisms of action. The latest clinical evidence of the anticancer effects of CBD is also outlined. Moreover, the main aspects of the pharmacological and toxicological profiles are given.
Copyright © 2018 Elsevier B.V. All rights reserved.
PMID: 31775230 DOI: 10.3390/ijms20235905
Kis B1,2, Ifrim FC3, Buda V4, Avram S1, Pavel IZ1, Antal D5, Paunescu V2,6, Dehelean CA7, Ardelean F5, Diaconeasa Z8, Soica C9, Danciu C1.
This article originally appeared here in https://www.weedworldmagazine.org/2019/12/05/medical-cannabis-brain-cancer-breast-cancer-cannabidiol-clinical-evidence-colon-cancer-glioma-immunomodulatory-effects-lung-cancer-melanoma-pharmacological-and-toxicological-profile-prostate-cancer/